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Preclinical Research and Animal Models in Sexual Medicine orgasmic response in women This re ex can be induced and studied in isolation by applying a mechanical stimulation to the urethra of anesthetized, spinalized female rats The urethro genital re ex includes rhythmic contractions of the vagina, uterus, and the anal sphincter, as well as the striated pelvic musculature Stimulation of the urethra may mimic stimulation of the anterior wall of the vagina, which is the area with the highest erotic sensitivity Indeed, the anterior wall of the vagina has a denser innervation than the posterior wall, and the distal area has more nerve bers than the proximal During copulation, female rats typically control the initiation and rate of contact with males In the same way that ejaculation is critical for conditioned sexual responses in males, the ability of female rats to pace their copulatory contact is critical for the induction of conditioned place or partner preferences As in males, these consequences of sexual stimulation are blocked by administration of the opioid antagonist naloxone, suggesting that opioid activation is a critical feature of the sexual reward experienced during paced copulation In addition, pacing imposes a delay between successive vaginal intromissions by the male This delay distributes the vaginocervical stimulation that females receive over time, an effect that enhances reproductive capability and fertility in the female Vaginocervical stimulation during orgasm in women may have a similar enhancing effect on reproductive capability

7

females to allow mounting by a male, with the lordosis re ex being the best known and most studied response Unfortunately, there is no counterpart for lordosis in women In contrast, psychologic arousal or desire in women is likely to be very close to proceptivity For this reason, the study of proceptive behaviors is also relevant to any preclinical investigation of potential of compounds for the treatment of female sexual disorders or dysfunctions (FSD) Indeed, recently it has been reported that the melanocortin agonist, PT-141, increased rates of sexual solicitation and hops and darts in female rats selectively This same drug increased female-initiated sexual activity in early Phase IIa clinical trials These two observations were critically important to begin to establish solicitation as a valid model of female sexual desire

tenants (to name just a few) to satisfy, you ll want to be sure you have a clear paper trail for your property that shows What you ve done When you ve done it Why you ve done it The information may seem mundane and maybe even obvious in the moment, but it may have a different meaning if someone sees the record without knowing the property in question Accurate records will ensure financial protection as well as protection from claims that you didn t do something you did in fact do If you replace locks on one or several apartments, record whether it was a routine refit or in response to security concerns Similarly, it may be important to keep a sheet for tenants to initial on receipt of new keys, safeguarding you from allegations that you changed locks without notice Records come in several forms, including the following: Financial, those relating to the finances of the property and its cash flow Contracts, such as tenancy agreements and associated records Maintenance, including maintenance schedules, when repairs were made, and fire equipment checked Administrative, including business licences, protocols regarding safety procedures, and sign-off sheets for receipt of keys and other items Here are some reasons to keep records: Government regulations: Various federal and provincial rules require you to keep records regarding your investment property Tax requirements are a primary reason to keep records, but Statistics Canada and other government departments may also request information regarding your business activities The federal Income Tax Act requires you to maintain records and books in an orderly manner at your place of business or your residence in case of a review or audit of your filings You must maintain all records and supporting documents for at least six years from the end of the last taxation year to which they relate If you filed your return late for any year, records and supporting documents must be kept for six years from the date you filed that return The Canada Revenue Agency permits computer storage of records as long as those records provide adequate information to verify tax claims.

a service that can enforce QoS policy, uses all three types of interworking [FRF8] Trunking services are the function of the main transport They carry bits between access points, interworking points, and internal network switches Trunks carry signaling as well as user information, although the signaling and user data may go by different systems within the provider network Classical telco trunks have used time-division multiplexing (TDM) or ATM Classical data trunks have a wider range of transports GMPLS is likely to be the transport control technique that unifies the data and voice worlds MPLS itself today runs over classical data transports, but these transports are themselves evolving with new optical technologies Where ATM might be used today, there is increasing use of packet over SONET (POS) and continued movement to direct IP over optical